Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy have become widely accepted as an effective methods of treating peritoneal metastases (PM) from various cancers. CRS is performed with the goal of removing all macroscopic diseases and comprises peritonectomy procedures and visceral resections. CRS is a technically challenging surgery that requires a considerable amount of skill and appropriate patient selection. This article is a review of the techniques and current recommendations for performing CRS. However, this is a complex treatment that is difficult to implement and careful patient selection is needed for obtaining good results. Cytoreductive surgery is performed with the goal of complete removal of all macroscopic diseases. This is achieved by peritonectomy procedures and en-bloc resection of the viscera where required. Their use depends on the extent of PM. The normal peritoneum is not excised, only that which is affected is removed.
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